Mpumi is the chairperson of the UN Global Compact SA board and the chairperson of Adcock Ingram. She is a director of numerous Bidvest subsidiaries and during her time at Bidvest, she has held various senior management and executive board director positions such as general manager business development, divisional director business development, corporate affairs director and sales and marketing director. She was previously chief director in the Gauteng provincial government. Appointed as non-executive director of the Adcock board of directors on 23 November 2017. Was appointed CEO‑designate on 4 March 2019.